Comparison of plasma and CSF Neurofilament light as outcome in a

We explored the value of an ultrasensitive single-molecule array (Simoa) serum NfL (sNfL) assay in multiple sclerosis (MS). The single molecule array (Simoa) assay technology is significantly more sensitive compared to conventional detection systems like ELISA or electrochemiluminescence immunoassays. Simoa allows reliable detection of NfL in individual serum samples. NFL was determined with Single Molecule Array (Simoa™) technology (detection threshold 1.95 pg/mL). “GE and the NFL clearly recognize the pressing need to better understand and accurately diagnose mild traumatic brain injury, and we’re honored to be able to showcase how our Simoa technology is able to do just that,” said Kevin Hrusovsky, CEO and Executive Chairman, Quanterix. Neurofilament light chains (NfL) are unique to neuronal cells, are shed to the cerebrospinal fluid (CSF), and are detectable at low concentrations in peripheral blood. Various diseases causing neuronal damage have resulted in elevated CSF concentrations.

Simoa nfl

The single molecule array (Simoa) assay technology is significantly more sensitive compared to conventional detection systems like ELISA or electrochemiluminescence immunoassays. Simoa allows reliable detection of NfL in individual serum samples. NFL was determined with Single Molecule Array (Simoa™) technology (detection threshold 1.95 pg/mL). “GE and the NFL clearly recognize the pressing need to better understand and accurately diagnose mild traumatic brain injury, and we’re honored to be able to showcase how our Simoa technology is able to do just that,” said Kevin Hrusovsky, CEO and Executive Chairman, Quanterix.

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Multiple sclerosis (MS) patients had significantly higher serum NfL levels than controls when measured with Simoa (p=0.001) but not with the other platforms. Various diseases causing neuronal damage have resulted in elevated CSF concentrations. We explored the value of an ultrasensitive single-molecule array (Simoa) serum NfL (sNfL) assay in multiple sclerosis (MS).

Plasma Concentration of the Neurofilament Light Protein NFL is a

The result is reported as ng/L. If urgent NfL-testing is required, please contact the laboratory at +46 40 53 76 60. “GE and the NFL clearly recognize the pressing need to better understand and accurately diagnose mild traumatic brain injury, and we’re honored to be able to showcase how our Simoa technology is able to do just that,” said Kevin Hrusovsky, CEO and Executive Chairman, Quanterix. Simoa® Assay Kits Ready-to-use Simoa® kits contain all the reagents necessary to run your assay on the HD-1, HD-X , SR-X or SP-X platforms. Our broad portfolio of available kits spans multiple therapeutic areas including cardiology, infectious disease, inflammation, neurology, and oncology.

Subscribe to our newsletter. Submit. info@ Simoa® Protein Assay Services. Based on a facility with two Quanterix Simoa® HD-1 Analyzers and our long-standing experience with this technology, we offer development, validation and screening of uniquely ultra-sensitive Simoa® biomarker assays, from pre-clinical samples, or, applying GCP standards, also from clinical samples.. Please email us for more information about our Simoa® services.
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With the newest addition to our technology platform, we are able to use a single molecule array digital ELISA (SIMOA) to evaluate neurofilament light chain (NfL) in serum. In serum, NfL levels in genetic FTD patients were more than 8 times higher than in controls and serum NfL levels showed a high correlation with CSF NfL levels. 11.

Click to learn more about NFL testing 2021-03-20 Objective: We present the results of plasma biomarker quantification in a cohort of spinocerebellar ataxia type-3 (SCA3) carriers using a Simoa assay. Background: Development of treatments for SCA3 will require the characterization of accessible and reliable biomarkers that could be used as outcome measures in clinical trials. Tau, neurofilament light-chain (NFL), glial fibrillary acidic Research and development of neurological tests including the Simoa N4PA assay is a result of two GE and NFL Head Health Challenge grants that have been awarded to Quanterix since 2015.
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35 The confirmation of these findings could lead to the worldwide implementation of NfL measurements in clinical chemistry laboratories. Neurofilament light chains (NfL) are unique to neuronal cells, are shed to the cerebrospinal fluid (CSF), and are detectable at low concentrations in peripheral blood. Various diseases causing neuronal damage have resulted in elevated CSF concentrations. Ready-to-use Simoa® kits contain all the reagents necessary to run your assay on the HD-1, HD-X , SR-X or SP-X platforms. Elevated CSF and blood concentrations of neurofilament light chain (NfL) were found to correlate with an increase in the number of relapses, disability worsening, MRI disease activity, and brain volume loss in MS. 3, –, 9 A highly sensitive single molecule array (SIMOA) immunoassay has recently been developed to measure NfL in blood. 6,10 Method: Serum NFL levels were detected using the Single Molecule Array (Simoa) technology in 30 ALS patients and 20 healthy controls (HCs). Results: There was a significant elevated levels of serum NFL in patients with ALS than in the HCs (P < 0.001).